Overall Score5
- Generality
- Reagent Availability
- Experimental User Friendliness
- Criteria #4
- Criteria #5
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General Characteristics
In order to tame the basicity and the high reactivity of amines during multi-step synthesis, it is common to protect them with electron-withdrawing functional groups. Carbamate meets this need well in terms of generality and the convenience of protection/deprotection, better than amide and sulfonamide. Carbamate protection is essential in peptide synthesis and used regularly in all other situations as well.
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General References
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Reaction Mechanism
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Examples
Commonly used carbamates are listed below. Each has its own deprotection conditions, allowing for orthogonal strategies.
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Experimental Procedure
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Experimental Tips
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References
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Related Books
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