General Characteristics Ketones can be synthesized by the palladium-catalyzed cross coupling between thioesters and boronic acids. The use of copper thiophene-2-carboxylate (CuTC) as an additive is ...
Tag Archives: palladium
Arylation at Lysine Residues
Pentelute and Buchwald et al. at MIT developed a method for chemoselective functionalization of peptides． “Palladium-Mediated Arylation of Lysine in Unprotected Peptides” Lee, H.-G.; Lautrette, G.; ...
C–H β-Sulfornyloxylation of Alcohols
Sp3 C–H β-Sulfornyloxylation of Alcohols Carbon–hydrogen bond activation (C–H activation) allows for the transformation of inherent C–H bonds within a molecule to various functional groups without ...
Buchwald-Hartwig Cross Coupling Reaction
General Characteristics -The palladium-catalyzed cross coupling between aryl halides/triflates and amines/alkoxides is known as the Buchwald-Hartwig reaction. The use of bidentate ligands (e.g. dppf, ...
Migita-Kosugi-Stille Cross Coupling Reaction
General Characteristics -The palladium-catalyzed cross coupling of organic halides or triflates with organotin compounds is known as the Migita-Kosugi-Stille coupling. -The reaction works under very ...
Negishi Cross Coupling Reaction
General Characteristics -While cross coupling reactions based on organolithium and Grignard reagents (Kumada-Tamao-Corriu cross coupling) tend to suffer from unwanted side reactions when applied to ...
Mizoroki-Heck Reaction
General Characteristics -The cross coupling reaction between an aryl/alkenyl halide and a terminal olefin in the presence of a Pd(0) catalyst to produce a substituted olefin is called the ...
Sonogashira-Hagiwara Cross Coupling Reaction
General Characteristics -The cross coupling reaction between an aryl or alkyl halide and a terminal alkyne catalyzed by the combination of Pd(0), copper iodide, and an amine is called the ...