Neutron Imaging Neutron version of radiography. This is a non-destructive method of visualizing the internal structure of a material by taking advantage of the high penetrating power of neutrons. It ...
Author Archive
NMR Chemical Shifts for Solvent Impurities
Reliable papers summarizing NMR data of various solvents in various heavy solvents are indispensable to organic chemists. In this post, four papers that contain NMR chemical shifts are presented: Why ...
Organolithium Reagents
Abstract The reactivity of organometallic reagents is roughly determined by the degree of polarization of carbon-metal bonds, with carbon-lithium bonds exhibiting the greatest polarization (ionic ...
Quick Guide to ChemDraw
ChemDraw is a well-known structure-drawing software. Although ChemDraw is an indispensable software for chemists, probably not many people can fully utilize its functions… (I am one of them)? ...
NMR Basics: Guide for Analysis and Interpretation
This post introduces NMR basics, focusing on the analysis and interpretation of the 1-D 1H and 13C NMR spectra. An overview of NMR basics, including principles, is available on the JEOL website. ...
How “good” can the synthetic route be? SMART-PMI: Predicting Process Mass Intensity from Molecular Structure
In the industrial production of pharmaceuticals, there is a strong demand to realize synthetic routes that are economical to produce and consider their environmental impact. From the perspective of ...
Solvent Isotope Effect
solvent isotope effect An isotope effect that appears when a solvent labeled with an isotope (especially deuterium) is utilized. In chemical research, there are many opportunities to investigate the ...
IR Basics: Guide for Analysis and Interpretation
Overview Infrared absorption spectrometry (IR) is an analytical method that measures the absorption spectrum obtained by exposing a sample to infrared light. IR is especially useful for determining ...
Grignard Reaction
General Characteristics Grignard reagents are the most popular among organometallic reagents. Alkyl groups can be introduced into carbonyl compounds to give the corresponding alcohols. The ...
Wittig Reaction
General Characteristics Compounds in which the adjacent anion is stabilized by a heteroatom with a positive formal charge are generally called ylides. The synthesis of alkenes from carbonyl compounds ...