A heavy drug is a drug labeled with deuterium (2H, D).[1] By replacing C-H bonds at metabolic sites in drug molecules with more stable C-D bonds, metabolism can be slowed down. This deuteration makes ...
Author Archive
Process Mass Intensity, PMI
Process Mass Intensity (PMI) is the total mass of material used to produce a product of a given mass, determined in units of mass of input material (e.g., kg) per mass of product (e.g., kg). The PMI ...
Complex Acid Chlorides from Unsaturated Hydrocarbons
Morandi at Max-Planck-Institut für Kohlenforschung developed an exchange reaction for producing functionalized acid chlorides． “CO- and HCl-free synthesis of acid chlorides from unsaturated ...
Ugi Reaction for Alternating Peptides
Koyama and Gudeangadi at Toyama Prefectural University developed an Ugi-reaction-based synthetic method of producing alternating peptides． “One-pot synthesis of alternating peptides exploiting a new ...
Arylation at Lysine Residues
Pentelute and Buchwald et al. at MIT developed a method for chemoselective functionalization of peptides． “Palladium-Mediated Arylation of Lysine in Unprotected Peptides” Lee, H.-G.; Lautrette, G.; ...