Prof. Scott E. Denmark et al. at the University of Illinois used three-dimensional molecular structures to enable machine learning to predict selectivity in asymmetric catalysis in 2019.[1] Later in ...
Author Archive
Louis E. Brus
Louis Eugene Brus (August 10, 1943 – Cleveland, Ohio) is an American chemist. He is a professor at Columbia University. He is a member of the National Academy of Sciences (photo: Columbia ...
Neutron time-of-flight scattering
Neutron time-of-flight scattering (meV ~eV) A rotating object called a chopper is used to determine the single neutron energy incident on the sample. The neutron energy after scattering is determined ...
EXSY (Exchange Spectroscopy, NMR)
What is EXSY? Abbreviation for EXchange SpectroscopY, a technique in NMR measurements. Another name for NOESY. The pulse sequences are identical to NOESY.[1,2] Since correlated signals also appear ...
Condensation Reagent
General Characteristics Esters and amides (peptides) can be obtained by condensing carboxylic acids with alcohols and amines under strongly acidic conditions (Fischer method). However, epimerization ...
What is DOI?
You have probably seen the above number written in the corner of a paper at least once. This is a code called DOI (Digital Object Identifier). What is DOI? A DOI is a code that corresponds to ...
O-Demethylation
Conversion of a methoxy group to a hydroxy group is sometimes a rather difficult task. The methyl group (alkyl group) is too stable to call it a protecting group, but synthesis from inexpensive ...
heavy drug (deuterated drug)
A heavy drug is a drug labeled with deuterium (2H, D).[1] By replacing C-H bonds at metabolic sites in drug molecules with more stable C-D bonds, metabolism can be slowed down. This deuteration makes ...
Process Mass Intensity, PMI
Process Mass Intensity (PMI) is the total mass of material used to produce a product of a given mass, determined in units of mass of input material (e.g., kg) per mass of product (e.g., kg). The PMI ...
Complex Acid Chlorides from Unsaturated Hydrocarbons
Morandi at Max-Planck-Institut für Kohlenforschung developed an exchange reaction for producing functionalized acid chlorides. “CO- and HCl-free synthesis of acid chlorides from unsaturated ...