General Characteristics Esters and amides (peptides) can be obtained by condensing carboxylic acids with alcohols and amines under strongly acidic conditions (Fischer method). However, epimerization ...
Author Archive
What is DOI?
You have probably seen the above number written in the corner of a paper at least once. This is a code called DOI (Digital Object Identifier). What is DOI? A DOI is a code that corresponds to ...
O-Demethylation
Conversion of a methoxy group to a hydroxy group is sometimes a rather difficult task. The methyl group (alkyl group) is too stable to call it a protecting group, but synthesis from inexpensive ...
heavy drug (deuterated drug)
A heavy drug is a drug labeled with deuterium (2H, D).[1] By replacing C-H bonds at metabolic sites in drug molecules with more stable C-D bonds, metabolism can be slowed down. This deuteration makes ...
Process Mass Intensity, PMI
Process Mass Intensity (PMI) is the total mass of material used to produce a product of a given mass, determined in units of mass of input material (e.g., kg) per mass of product (e.g., kg). The PMI ...
Complex Acid Chlorides from Unsaturated Hydrocarbons
Morandi at Max-Planck-Institut für Kohlenforschung developed an exchange reaction for producing functionalized acid chlorides． “CO- and HCl-free synthesis of acid chlorides from unsaturated ...
Ugi Reaction for Alternating Peptides
Koyama and Gudeangadi at Toyama Prefectural University developed an Ugi-reaction-based synthetic method of producing alternating peptides． “One-pot synthesis of alternating peptides exploiting a new ...
Arylation at Lysine Residues
Pentelute and Buchwald et al. at MIT developed a method for chemoselective functionalization of peptides． “Palladium-Mediated Arylation of Lysine in Unprotected Peptides” Lee, H.-G.; Lautrette, G.; ...