Posts by Category: Reactions

Boyland-Sims Oxidation

Boyland-Sims Oxidation

General Characteristics Anilines can be converted into aminophenols by the reaction called the Boyland-Sims oxidation. Ortho-hydroxylated products are usually obtained preferentially. The oxidation ...

Read more
Mukaiyama Condensation Reagent

Mukaiyama Condensation Reagent

General Characteristics First introduced in 1970’s, 2-halo-N-alkylpyridinium salts are called the Mukaiyama reagent and used for condensation reactions such as esterification and amide bond ...

Read more
Betti Reaction

Betti Reaction

General Characteristics The three component condensation reaction among aldehydes, amines, and phenols is known as the Betti reaction. This reaction is the phenol version of the Mannich reaction. ...

Read more
Pinner Reaction

Pinner Reaction

General Characteristics The treatment of nitriles with HCl-anhydrous alcohol generates imidate salts, which can be converted into amidines and orthoesters using amines and alcohols, respectively. The ...

Read more
Hell-Volhard-Zelinsky Reaction

Hell-Volhard-Zelinsky Reaction

General Characteristics The classical method to convert carboxylic acids into α-haloacyl halides using phosphorus(III) halide is known as the Hell-Volhard-Zelinsky reaction. General References Hell, ...

Read more
Norrish Reaction

Norrish Reaction

General Characteristics Upon photo-irradiation, carbonyl compounds undergo carbon-carbon bond cleavage reactions via biradical intermediates. The first type involves the formation of acyl radicals ...

Read more
de Mayo Reaction

de Mayo Reaction

General Characteristics In the de Mayo reaction, 1,3-dicarboyl compounds and alkenes undergo photo-activated [2+2] cycloaddition. The subsequent ring opening gives 1,5-dicarbonyl products. General ...

Read more
Cornforth Rearrangement

Cornforth Rearrangement

General Characteristics Oxazole compounds containing a carbonyl group at 4-position are known to undergo thermally driven rearrangement. Thiazoles have the similar property as well. General ...

Read more
Reductvie Desulfurization

Reductvie Desulfurization

General Characteristics Thioethers and thioacetals can be reductively desulfurized by treating them with Raney nickel. The reduction of the latter is a common way to deoxygenate carbonyl groups. ...

Read more
Blaise Reaction

Blaise Reaction

General Characteristics In the Blaise reaction, nitriles and zinc-enolates (prepared from zinc and α-haloesters) react to give β-enaminoesters or β-ketoesters. General References Blaise, E. E. Compt. ...

Read more