Author Archive

Troc Protecting Group

Troc Protecting Group

General Characteristics 2,2,2-Trichloroethoxycarbonyl (Troc) group is a commonly used carbamate protecting group for amines. It is also used to protect alcohols and phenols. Troc group is stable ...

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Teoc Protecting Group

Teoc Protecting Group

General Characteristics 2-(Trimethylsilyl)ethoxycarbonyl (Teoc) group is one of commonly used carbamate protecting groups for amines. It is stable towards hydrolysis and other nucleophilic attacks, ...

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Kita Esterification

Kita Esterification

General Characteristics Under the conditions developed by Kita, esters are synthesized from the corresponding alcohols and carboxylic acids using a ruthenium catalyst and ethynyl ethyl ether as a ...

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Chan Rearrangement

Chan Rearrangement

General Characteristics The treatment of α-acyloxyesters with a strong base triggers rearrangement that leads to the formation of α-hydroxy-β-ketoesters. General References S. D. Lee, T. H. Chan, K. ...

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Shono Oxidation

Shono Oxidation

General Characteristics In the Shono oxidation, amides or carbamates in alcohol solvents are electrochemically oxidized to give N,O-acetals. This electrochemical reaction provides a useful way to ...

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SnAP Reagent

SnAP Reagent

General Characteristics SnAP (Sn(tin) Amine Protocol) reagents provide an easy access to a variety of saturated heterocycles and amines containing a spiro skeleton. The simple two-step procedure ...

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Krapcho Decarboxylation

Krapcho Decarboxylation

General Characteristics β-Keto methyl esters undergo decarboxylation under near neutral conditions upon heating in the presence of lithium chloride in DMSO. This reaction is particularly useful when ...

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Marko-Lam Deoxygenation

Marko-Lam Deoxygenation

General Characteristics The deoxygenation of alcohols via p-toluic acid esters under single-electron reduction conditions is known as the Marko-Lam deoxygenation. It has advantages over the ...

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Pomeranz-Fritsch Isoquinoline Synthesis

Pomeranz-Fritsch Isoquinoline Synthesis

General Characteristics The condensation of benzaldehydes or arylketones with aminoacetaldehyde acetals gives isoquinolines. Alternatively, the condensation of benzylamines with glyoxal hemiacetals ...

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Kornblum Oxidation

Kornblum Oxidation

General Characteristics Alkyl halides can be converted into the corresponding aldehydes by thermally driven displacement by DMSO followed by treatment with bases. General References ・Kornblum, N.; ...

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