Pomeranz-Fritsch Isoquinoline Synthesis

Pomeranz-Fritsch Isoquinoline Synthesis

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The condensation of benzaldehydes or arylketones with aminoacetaldehyde acetals gives isoquinolines.

Alternatively, the condensation of benzylamines with glyoxal hemiacetals also works for synthesizing the same products (the Schlittler-Muller modification).

  • General References

Pomeranz, C. Monatsh 1893, 14, 116.

Fritsch, P. Ber. 1893, 26, 419.

Schlittler, E.; Muller, J. Helv. Chim. Acta 194831, 914, 1119.

  • Reaction Mechanism

  • Examples

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  • References

  • Related Reactions

 Povarov Reaction

Camps Quinoline Synthesis

Conrad-Limpach Quinoline Synthesis

Combes Quinoline Synthesis

Niementowski Quinoline/Quinazoline Synthesis

Bischler-Napieralski Isoquinoline Synthesis

Pfitzinger Quinoline Synthesis

Skraup Quinoline Synthesis

Knorr Quinoline Synthesis

Friedländer Quinoline Synthesis

Pictet-Gams Isoquinoline Synthesis

Doebner-von Miller quinoline synthesis

Pictet-Spengler Reaction

Reissert Reaction

  • Related Books

  • External Links

Isoquinoline – Wikipedia