General Characteristics Esters and amides (peptides) can be obtained by condensing carboxylic acids with alcohols and amines under strongly acidic conditions (Fischer method). However, epimerization ...
Tag Archives: macrolactonization
Yamaguchi Macrolactonization
General Characteristics In the method developed by Yamaguchi, hydroxycarboxylic acids (“seco-acids”) are converted into reactive acid anhydrides using 2,4,6-trichlorobenzoyl chloride ...
Corey-Nicolaou Macrolactonization
General Characteristics The macrolactonization reaction using 2,2’-dipyridyldisulfide and triphenylphosphine is known as the Corey-Nicolaou reaction. The cyclization step usually requires a high ...