Tag Archives: macrolactonization

Yamaguchi Macrolactonization

Yamaguchi Macrolactonization

General Characteristics In the method developed by Yamaguchi, hydroxycarboxylic acids (“seco-acids”) are converted into reactive acid anhydrides using 2,4,6-trichlorobenzoyl chloride ...

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Corey-Nicolaou Macrolactonization

Corey-Nicolaou Macrolactonization

General Characteristics The macrolactonization reaction using 2,2’-dipyridyldisulfide and triphenylphosphine is known as the Corey-Nicolaou reaction. The cyclization step usually requires a high ...

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