Prof. Scott E. Denmark et al. at the University of Illinois used three-dimensional molecular structures to enable machine learning to predict selectivity in asymmetric catalysis in 2019.[1] Later in ...
Posts by Category: OrganicChem
Process Mass Intensity, PMI
Process Mass Intensity (PMI) is the total mass of material used to produce a product of a given mass, determined in units of mass of input material (e.g., kg) per mass of product (e.g., kg). The PMI ...
Complex Acid Chlorides from Unsaturated Hydrocarbons
Morandi at Max-Planck-Institut für Kohlenforschung developed an exchange reaction for producing functionalized acid chlorides． “CO- and HCl-free synthesis of acid chlorides from unsaturated ...
Ugi Reaction for Alternating Peptides
Koyama and Gudeangadi at Toyama Prefectural University developed an Ugi-reaction-based synthetic method of producing alternating peptides． “One-pot synthesis of alternating peptides exploiting a new ...
Arylation at Lysine Residues
Pentelute and Buchwald et al. at MIT developed a method for chemoselective functionalization of peptides． “Palladium-Mediated Arylation of Lysine in Unprotected Peptides” Lee, H.-G.; Lautrette, G.; ...
Near-Infrared Light Activated Azo-BF2 Switches
Yang, Y.; Hughes, R. P.; Aprahamian, I. J. Am. Chem. Soc. 2014, 136 ,13190–13193 DOI: 10.1021/ja508125n ABSTRACT: Increasing the electron density in BF2- coodinated azo compounds through ...
Metal-Free Hydrogenation Catalyzed by an Air-Stable Borane: Use of Solvent as a Frustrated Lewis Base
Scott, D. J.; Fuchter, M. J.; Ashley, A. E. Angew. Chem. Int. Ed. 53, 2014. 53, 10218. DOI: 10.1002/anie.201405531 In recent years “frustrated Lewis pairs” (FLPs) have been shown to be effective ...
Far-Red Fluorescence Probe for Monitoring Singlet Oxygen during Photodynamic Therapy
S, Kim.;T, Tachikawa.; M, Fujitsuka.; T, Majima. J. Am. Chem. Soc. 2014. 136, 11707. DOI: 10.1021/ja504279r Singlet oxygen (1O2), molecular oxygen in thelowest excited state, has a critical role in ...
Arylazopyrazoles: Azoheteroarene Photoswitches Offering Quantitative Isomerization and Long Thermal Half-Lives
Weston. C. E; Richardson, R.; Haycock, P.; White, A.; Fuchter, M. J. Am. Chem. Soc. 2014, 136, 11878. DOI: 10.1021/ja505444d Arylazopyrazoles, a novel class of five-membered azo photoswitches, ...
Quantitative Photoswitching in Bis(dithiazole)ethene Enables Modulation of Light for Encoding Optical Signals
Yue Wu, Yongshu Xie, Qiong Zhang, He Tian, Weihong Zhu, and Alexander D. Q. Li, Angew. Chem. Int. Ed. 2014, 53, 2090. DOI: 10.1002/anie.201309915 Using one ray of light to encode another ray ...