Jean-Pierre Sauvage (10/21/1944 -) is a French supermolecular chemist (Photo: Université de Strasbourg). Prof. Sauvage shares the Nobel Prize in Chemistry 2016 with Prof. Fraser Stoddart and Prof. ...
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Noyori Asymmetric Hydrogenation
General Characteristics The asymmetric hydrogenation of olefins and ketones catalyzed by Ru(II)-BINAP and related ruthenium complexes is called the Noyori hydrogenation. The hydrogenation of olefins ...
Sharpless Asymmetric Dihydroxylation (Sharpless AD)
General Characteristics -Sharpless developed chiral ligands ((DHQD)2PHAL or (DHQ)2PHAL) derived from cinchona alkaloids (quinidine, quinine) for the practical osmium tetroxide-catalyzed asymmetric ...
Sharpless-Katsuki Asymmetric Epoxidation (Sharpless AE)
General Characteristics -The asymmetric epoxidation of allylic alcohols using catalytic Ti(OiPr)4, diethyl tartrate (DET), and t-butyl hydroperoxide (TBHP) is known as the Sharpless-Katsuki reaction. ...
Brown Hydroboration
General Characteristics -Alkenes can be converted into anti-Markovnikov alcohols by the Brown hydroboration, which involves regio/stereoselective syn-addition of a B-H bond to the olefin followed by ...
Olefin Metathesis
General Characteristics In the presence of a metal alkylidene catalyst, two olefins combine and redistribute their fragments to give a new pair of olefins. Olefin metathesis is fundamentally an ...
Negishi Cross Coupling Reaction
General Characteristics -While cross coupling reactions based on organolithium and Grignard reagents (Kumada-Tamao-Corriu cross coupling) tend to suffer from unwanted side reactions when applied to ...
Mizoroki-Heck Reaction
General Characteristics -The cross coupling reaction between an aryl/alkenyl halide and a terminal olefin in the presence of a Pd(0) catalyst to produce a substituted olefin is called the ...