Louis Eugene Brus (August 10, 1943 – Cleveland, Ohio) is an American chemist. He is a professor at Columbia University. He is a member of the National Academy of Sciences (photo: Columbia ...
Tag Archives: nobel prize
Jean-Pierre Sauvage
Jean-Pierre Sauvage (10/21/1944 -) is a French supermolecular chemist (Photo: Université de Strasbourg). Prof. Sauvage shares the Nobel Prize in Chemistry 2016 with Prof. Fraser Stoddart and Prof. ...
Noyori Asymmetric Hydrogenation
General Characteristics The asymmetric hydrogenation of olefins and ketones catalyzed by Ru(II)-BINAP and related ruthenium complexes is called the Noyori hydrogenation. The hydrogenation of olefins ...
Sharpless Asymmetric Dihydroxylation (Sharpless AD)
General Characteristics -Sharpless developed chiral ligands ((DHQD)2PHAL or (DHQ)2PHAL) derived from cinchona alkaloids (quinidine, quinine) for the practical osmium tetroxide-catalyzed asymmetric ...
Sharpless-Katsuki Asymmetric Epoxidation (Sharpless AE)
General Characteristics -The asymmetric epoxidation of allylic alcohols using catalytic Ti(OiPr)4, diethyl tartrate (DET), and t-butyl hydroperoxide (TBHP) is known as the Sharpless-Katsuki reaction. ...
Brown Hydroboration
General Characteristics -Alkenes can be converted into anti-Markovnikov alcohols by the Brown hydroboration, which involves regio/stereoselective syn-addition of a B-H bond to the olefin followed by ...
Olefin Metathesis
General Characteristics In the presence of a metal alkylidene catalyst, two olefins combine and redistribute their fragments to give a new pair of olefins. Olefin metathesis is fundamentally an ...
Negishi Cross Coupling Reaction
General Characteristics -While cross coupling reactions based on organolithium and Grignard reagents (Kumada-Tamao-Corriu cross coupling) tend to suffer from unwanted side reactions when applied to ...
Mizoroki-Heck Reaction
General Characteristics -The cross coupling reaction between an aryl/alkenyl halide and a terminal olefin in the presence of a Pd(0) catalyst to produce a substituted olefin is called the ...