General Characteristics Nucleophilic phosphorus reagents such as triphenylphosphine react with azides to generate, via the Staudinger reaction, N-P ylide (iminophosphorane) intermediates, which react ...
Tag Archives: synthesis of amines
Curtius Rearrangement
General Characteristics -Upon heating, acyl azides undergo rearrangement to give isocyanates with the loss of N2. In the presence of water, the isocyanates are immediately hydrolyzed to give amines ...
Fukuyama Amine Synthesis
General Characteristics -The Fukuyama amine synthesis provides a powerful way to access secondary amines under mild reaction conditions. -Nitrobenzenesulfonamides (nosyl (Ns) amides) are acidic ...