Tag Archives: synthesis of amines

Aza-Wittig Reaction

Aza-Wittig Reaction

General Characteristics Nucleophilic phosphorus reagents such as triphenylphosphine react with azides to generate, via the Staudinger reaction, N-P ylide (iminophosphorane) intermediates, which react ...

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Curtius Rearrangement

Curtius Rearrangement

General Characteristics -Upon heating, acyl azides undergo rearrangement to give isocyanates with the loss of N2. In the presence of water, the isocyanates are immediately hydrolyzed to give amines ...

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Fukuyama Amine Synthesis

Fukuyama Amine Synthesis

General Characteristics -The Fukuyama amine synthesis provides a powerful way to access secondary amines under mild reaction conditions. -Nitrobenzenesulfonamides (nosyl (Ns) amides) are acidic ...

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