Kornblum Oxidation

Kornblum Oxidation

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  • General Characteristics

Alkyl halides can be converted into the corresponding aldehydes by thermally driven displacement by DMSO followed by treatment with bases.

  • General References

・Kornblum, N.; Jones, W. J.; Anderson, G. J. J. Am. Chem. Soc. 1959, 81, 4113. DOI: 10.1021/ja01524a080
・Kornblum, N.; Jones, W. J.; Anderson, G. J.; Powers, J. W.; Larson, H. O.; Levand, O.; Wraver, W. M. J. Am. Chem. Soc. 195779, 6562. DOI: 10.1021/ja01581a057
・Dave, P.; Byun, H. S.; Engel, R. Synth. Commun. 198616, 1343.

  • Reaction Mechanism

The reaction mechanism is analogous to other DMSO-based oxidation reactions, and thus an equivalent of dimethylsulfide is produced as byproduct.

  • Examples

  • Experimental Procedure

  • Experimental Tips

  • References

  • Related Reactions

アルブライト・ゴールドマン酸化 Albright-Goldman Oxidation

パリック・デーリング酸化 Parikh-Doering Oxidation

フィッツナー・モファット酸化 Pfitzner-Moffatt Oxidation

コーリー・キム酸化 Corey-Kim Oxidation

向山酸化 Mukaiyama Oxidation

スワーン酸化 Swern Oxidation

  • Related Books


  • External Links

Oxidations (PDF)

Kornblum Oxidation – Wikipedia


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