Kornblum Oxidation

14 January, 2018 / by SK / in Reactions

4014

Overall Score4

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Criteria #4
Criteria #5

General Characteristics

Alkyl halides can be converted into the corresponding aldehydes by thermally driven displacement by DMSO followed by treatment with bases.

General References

・Kornblum, N.; Jones, W. J.; Anderson, G. J. J. Am. Chem. Soc. 1959, 81, 4113. DOI: 10.1021/ja01524a080
・Kornblum, N.; Jones, W. J.; Anderson, G. J.; Powers, J. W.; Larson, H. O.; Levand, O.; Wraver, W. M. J. Am. Chem. Soc. 1957, 79, 6562. DOI: 10.1021/ja01581a057
・Dave, P.; Byun, H. S.; Engel, R. Synth. Commun. 1986, 16, 1343.