Liebeskind-Srogl Cross Coupling

Liebeskind-Srogl Cross Coupling

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  • Generality
  • Reagent Availability
  • Experimental User Friendliness
  • General Characteristics

Ketones can be synthesized by the palladium-catalyzed cross coupling between thioesters and boronic acids.

The use of copper thiophene-2-carboxylate (CuTC) as an additive is important for the reaction.

  • General References

Liebeskind, L. S.; Srogl, J. J. Am. Chem. Soc. 2000122, 11260. doi:10.1021/ja005613q

Yu, Y.; Liebeskind, L. S. J. Org. Chem. 200469, 3554. doi:10.1021/jo049964p

Villalobos, J. M.; Srogl, J.; Liebeskind, L. S. J. Am. Chem. Soc. 2007129, 157324. doi:10.1021/ja074931n

  • Reaction Mechanism

  • Examples

  • Experimental Procedure

  • Experimental Tips

  • References

  • Related Reactions

 Fukuyama Cross Coupling

Larock Indole Synthesis

Chan-Lam-Evans Coupling

Miyaura-Ishiyama-Hartwig Borylation

Tsuji-Trost Reaction

 Hiyama Cross Coupling

 Kumada-Tamao-Corriu Cross Coupling

 Fukuyama Reduction

Buchwald-Hartwig Cross Coupling

Negishi Cross Coupling

 Migita-Kosugi-Stille Cross Coupling

反応 Mizoroki-Heck Reaction

 Sonogashira-Hagihara Cross Coupling

Suzuki-Miyaura Cross Coupling

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