General Characteristics Esters and amides (peptides) can be obtained by condensing carboxylic acids with alcohols and amines under strongly acidic conditions (Fischer method). However, epimerization ...
Tag Archives: peptides
Ugi Reaction for Alternating Peptides
Koyama and Gudeangadi at Toyama Prefectural University developed an Ugi-reaction-based synthetic method of producing alternating peptides． “One-pot synthesis of alternating peptides exploiting a new ...
Arylation at Lysine Residues
Pentelute and Buchwald et al. at MIT developed a method for chemoselective functionalization of peptides． “Palladium-Mediated Arylation of Lysine in Unprotected Peptides” Lee, H.-G.; Lautrette, G.; ...
Serine-Selective Aerobic Cleavage of Peptides and a Protein Using a Water-Soluble Copper–Organoradical Conjugate
Seki, Y.; Tanabe, K.; Sasaki, D.; Sohma, Y.; Oisaki, K.; Kanai, M. Angew. Chem. Int. Ed. 2014, 53, Early View. DOI: 10.1002/anie.201402618 The site-specific cleavage of peptide bonds is an important ...
Robert B. Merrifield
Robert Bruce Merrifield, (1921-) is an American biochemist who won the 1984 Nobel Prize in chemistry for his method of producing peptides and proteins. He revolutionized the study of these complex ...
Merrifield Solid-Phase Peptide Synthesis
Characteristics A protein consists of one peptide folded in a particular way, or several peptides folded together. Such peptides are synthesised very rapidly within living cells, but until recently ...
Erythropoietin Derived by Chemical Synthesis
Wang, P.; Dong, S.; Shieh, J.-H.; Peguero, E.; Hendrickson, R.; Moore, M. A. S.; Danishefsky, S. J. Science 2013, 342, 1357–1360. DOI: 10.1126/science.1245095 Erythropoietin is a signaling ...