Author Archive

Camps Quinoline Synthesis

Camps Quinoline Synthesis

General Characteristics The basic treatment of ortho-acylaminoacetophenones leads to cyclocondensation, producing hydroxyquinolines. The experimenter needs to be aware of possible isomer formation. ...

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Benzyne

Benzyne

General Characteristics The dehydrogenated form of benzene (the benzene minus two hydrogen atoms) is commonly called benzyne. There are three regioisomers. o-Benzyne, in which the ortho hydrogens are ...

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Baldwin’s Rule

Baldwin’s Rule

General Characteristics The rate of ring closing reactions is largely influenced by how easily the orbitals can interact and overlap at the reacting parts of the molecule. The empirical rule that ...

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Fenton Reaction

Fenton Reaction

General Characteristics The hydroxyl radical generated from H2O2 in the presence of iron(II) is used to promote various decomposition reactions. Copper(I) is known to have a similar property as well. ...

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Fetizon’s Reagent

Fetizon’s Reagent

General Characteristics Silver(I) carbonate supported on Celite is called the Fetizon’s reagent. It is a mild oxidizing agent and particularly useful for the oxidation of lactols to lactones. ...

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Tungstate Photocatalyst

Tungstate Photocatalyst

General Characteristics Tetrakis(tetrabutylammonium) decatungstate (TBADT) is an organic solvent-soluble polyoxometalate compound that can act as a C-H abstraction catalyst under UV-activated ...

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SO2 Incorporation Using DABSO

SO2 Incorporation Using DABSO

General Characteristics Sulfur dioxide (SO2) is a synthetically useful reagent as a source of sulfur but it has to be used with care in a well-ventilated hood since it is a toxic gas. DABSO, the ...

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Eschenmoser Coupling

Eschenmoser Coupling

General Characteristics The Eschenmoser coupling begins with the S-alkylation of thioamides and gives enamine products (vinylogous amides, urethanes, etc.). As shown below, thiophiles (e.g. ...

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Duff Reaction

Duff Reaction

General Characteristics The formylation of phenols and anilines using hexamethylenetetramine is known as the Duff reaction. General References Duff, J. C.; Bills, E. J. J. Chem. Soc. 1932, 1987; ...

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