General Characteristics Aromatic rings and alkenes undergo [3+2] cycloaddition under photo-irradiated conditions. This reaction provides complex fused ring skeletons that are otherwise difficult to ...
Author Archive
Edman Degradation
General Characteristics The Edman degradation is a way to determine the primary structure of peptides. Phenyl isocyanate reacts with the N-terminus amino acid residue and only that residue is cleaved ...
Barton Vinyl Iodide Synthesis
General Characteristics Hydrazones can be converted into vinyl iodides using molecular iodine under mild conditions. Vinyl selenides can be synthesized as well in similar manner using reagents such ...
Charette Asymmetric Cyclopropanation
General Characteristics The Simmons-Smith cyclopropanation can be rendered asymmetric by using the chiral boronic acid ester as a reagent. An allylic hydroxyl group is needed in substrates as a ...
Samarium(II) Iodide
General Characteristics Samarium(II) iodide (SmI2) is a mild one-electron reducing agent used for various reductive reactions of carbonyl compounds, organic halides, and electron deficient olefins. ...
Prato Reaction
General Characteristics The derivatization of fullerenes using azomethine ylides via 1,3-dipoloar cycloaddition was developed by Prato. This methodology is applicable to carbon nanotubes as well. ...
Rosenmund-von Braun Reaction
General Characteristics Aromatic nitriles can be synthesized from the corresponding aryl halides using copper(I) cyanide. The reaction tends to require high temperature conditions but is ...
Thiol-ene Reaction
General Characteristics Thiols and alkenes undergo free-radical mediated S-C bond formation known as thiol-ene reaction. Thanks to its high chemoselectivity and functional group tolerance, it is ...
Thorpe-Ingold Effect
General Characteristics The effect of geminal substitution in linear molecules that promotes cyclization is referred to as the Thorpe-Ingold effect (aka. gem-dialkyl effect). General References ...
Bioconjugation
General Characteristics Bioconjugation is a process of covalently functionalizing biological molecules. It is most relevant to protein chemistry and is one of the newest topics in reaction ...