Rosenmund-von Braun Reaction

Rosenmund-von Braun Reaction

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  • General Characteristics

Aromatic nitriles can be synthesized from the corresponding aryl halides using copper(I) cyanide. The reaction tends to require high temperature conditions but is straightforward operationally.

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  • Reaction Mechanism


  • Examples

The newer modified method uses a substoichiometric amount of copper.[1]


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  • References

[1] Zanon, J.; Klapars, A.; Buchwald, S. L. J. Am. Chem. Soc. 2003, 125, 2890. DOI: 10.1021/ja0299708

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