General Characteristics Silver(I) carbonate supported on Celite is called the Fetizon’s reagent. It is a mild oxidizing agent and particularly useful for the oxidation of lactols to lactones. ...
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Tungstate Photocatalyst
General Characteristics Tetrakis(tetrabutylammonium) decatungstate (TBADT) is an organic solvent-soluble polyoxometalate compound that can act as a C-H abstraction catalyst under UV-activated ...
SO2 Incorporation Using DABSO
General Characteristics Sulfur dioxide (SO2) is a synthetically useful reagent as a source of sulfur but it has to be used with care in a well-ventilated hood since it is a toxic gas. DABSO, the ...
Eschenmoser Coupling
General Characteristics The Eschenmoser coupling begins with the S-alkylation of thioamides and gives enamine products (vinylogous amides, urethanes, etc.). As shown below, thiophiles (e.g. ...
Duff Reaction
General Characteristics The formylation of phenols and anilines using hexamethylenetetramine is known as the Duff reaction. General References Duff, J. C.; Bills, E. J. J. Chem. Soc. 1932, 1987; ...
Hypervalent Iodine Reagents
General Characteristics Iodine can exist in high valence states because of its higher polarizability and smaller electronegativity compared with other halogen elements. Hypervalent iodine compounds ...
Kinugasa Reaction
General Characteristics In the presence of copper catalysts, nitrones and terminal alkynes undergo 1,3-dipolar cycloaddition to give β-lactams. General References Kinugasa, M.; Hashimoto, S. J. Chem. ...
MAC Reagent
General Characteristics Dicyanomethyl acetate, known as MAC (Masked Acyl Cyanide) reagent, is an acyl anion equivalent used for one-carbon homologation of aldehydes and imines. This reagent can be ...
AjiPhase Peptide Synthesis
General Characteristics The advantages of liquid-phase peptide synthesis (LPPS) over solid-phase synthesis (SPPS) include the use of reduced reagents and solvents and the ease of scaling up. The main ...
Mander’s Reagent
General Characteristics Methyl cyanoformate, also known as Mander’s reagent, is used to introduce a methoxycarbonyl group to metal enolates for the synthesis of β-ketoesters. Compared with ...