General Characteristics The thermal rearrangement of O-thiocarbamates into S-thiocarbamates is an effective way to synthesize thiophenols from phenols. The rearrangement usually requires very high ...
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Sonication in Organic Synthesis
General Characteristics Even though the rate acceleration effect of sonication has been long known, its application to organic synthesis is becoming popular only relatively recently. The development ...
Hanessian-Hullar Reaction
General Characteristics By the treatment with N-bromosuccinimide (NBS), benzylidene acetals can be oxidatively opened. The bromine ends up on the less hindered side of the two hydroxyl groups. ...
Mukaiyama Hydration
General Characteristics The hydration of alkenes using catalytic cobalt and stoichiometric silane under aerobic conditions was developed by Mukaiyama. The regioselectivity follows the ...
Wulff-Dotz Reaction
General Characteristics The synthesis of phenols by reacting [alkoxy(vinyl)carbene]pentacarbonylchromium complexes (Fischer carbene complex) with alkenes is called the Wulff-Dotz reaction. The ...
Povarov Reaction
General Characteristics The condensation of aldehydes, anilines, and electron-rich alkenes provides access to substituted tetrahydroquinoline skeletons. This is a type of three-component reaction ...
Visible Light Photoredox Catalyst
General Characteristics Transition metal complexes such as ruthenium(II) polypyridyl and iridium(III) phenylpyridyl are known to function as photoredox catalysts under irradiated conditions with ...
Minisci Reaction
General Characteristics The Minisci reaction allows for the direct functionalization of electron deficient hetero aromatic rings with carbon radicals. The radical precursor is most commonly the ...
Di-π-methane Rearrangement
General Characteristics 1,4-Dienes undergo light-promoted rearrangement to give vinylcyclopropanes. The scope of this reaction includes dienes containing heteroatoms such as oxygen and nitrogen and ...
Norrish-Yang Reaction
General Characteristics In the Norrish-Yang reaction, the C-H bond at the γ-position of ketones is homolytically cleaved by photo-irradiation and the ensuing rearrangement leads to the formation of ...