General Characteristics In the de Mayo reaction, 1,3-dicarboyl compounds and alkenes undergo photo-activated [2+2] cycloaddition. The subsequent ring opening gives 1,5-dicarbonyl products. General ...
Author Archive
Cornforth Rearrangement
General Characteristics Oxazole compounds containing a carbonyl group at 4-position are known to undergo thermally driven rearrangement. Thiazoles have the similar property as well. General ...
Reductvie Desulfurization
General Characteristics Thioethers and thioacetals can be reductively desulfurized by treating them with Raney nickel. The reduction of the latter is a common way to deoxygenate carbonyl groups. ...
Blaise Reaction
General Characteristics In the Blaise reaction, nitriles and zinc-enolates (prepared from zinc and α-haloesters) react to give β-enaminoesters or β-ketoesters. General References Blaise, E. E. Compt. ...
Synthesis of N-Oxide
General Characteristics Amines are susceptible to oxidation. Tertiary amines are oxidized to give N-oxides. Secondary amines having proton(s) at the α-position are oxidized to nitrones. The ...
L/N/K-Selectride
General Characteristic The reagents having the formula M[HB(sec-Bu)3] are used as reducing agents. There are three types with different cations: L-Selectride (lithium), N-Selectride (sodium), and ...
Conia-Ene Reaction
General Characteristics In the Conia-ene reaction, the enol and the alkene or alkyne parts of an unsaturated carbonyl compound react and undergo intramolecular cyclization. General References ...
Bucherer-Bergs Hydantoin Synthesis
General Characteristics Hydantoins can be synthesized from the corresponding ketones or aldehydes using potassium cyanide and ammonium carbonate. General References Bergs H, DE, 566, 094, 1929 ...
Bechamp Reduction
General Characteristics The reduction of aromatic nitro group using iron powder and HCl is called the Bechamp reduction. Besides these classical conditions, other reagents such as tin(II) chloride ...