Author Archive

Blaise Reaction

Blaise Reaction

General Characteristics In the Blaise reaction, nitriles and zinc-enolates (prepared from zinc and α-haloesters) react to give β-enaminoesters or β-ketoesters. General References Blaise, E. E. Compt. ...

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Synthesis of N-Oxide

Synthesis of N-Oxide

General Characteristics Amines are susceptible to oxidation. Tertiary amines are oxidized to give N-oxides. Secondary amines having proton(s) at the α-position are oxidized to nitrones. The ...

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Red-Al

Red-Al

General Characteristics Sodium bis(2-methoxyethoxy)aluminum hydride is a reducing agent sold with the common name Red-Al or Vitride. Red-Al can selectively reduce nitriles to aldehydes. It is more ...

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L/N/K-Selectride

L/N/K-Selectride

General Characteristic The reagents having the formula M[HB(sec-Bu)3] are used as reducing agents. There are three types with different cations: L-Selectride (lithium), N-Selectride (sodium), and ...

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Conia-Ene Reaction

Conia-Ene Reaction

General Characteristics In the Conia-ene reaction, the enol and the alkene or alkyne parts of an unsaturated carbonyl compound react and undergo intramolecular cyclization. General References ...

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Bucherer-Bergs Hydantoin Synthesis

Bucherer-Bergs Hydantoin Synthesis

General Characteristics Hydantoins can be synthesized from the corresponding ketones or aldehydes using potassium cyanide and ammonium carbonate. General References Bergs H, DE, 566, 094, 1929 ...

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Bechamp Reduction

Bechamp Reduction

General Characteristics The reduction of aromatic nitro group using iron powder and HCl is called the Bechamp reduction. Besides these classical conditions, other reagents such as tin(II) chloride ...

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McFadyen-Stevens Reaction

McFadyen-Stevens Reaction

General Characteristics The thermal decomposition of acylarylsulfonylhydrazines into the corresponding aldehydes under basic conditions is known as the McFadyen-Stevens reaction. The reaction has ...

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Kolbe Electrolysis

Kolbe Electrolysis

General Characteristics The decarboxylation of carboxylic acids and dimerization of the R group under electrolytic conditions is known as the Kolbe electrolysis. General References Kolbe, H. Ann. ...

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Hinsberg Oxindole Synthesis

Hinsberg Oxindole Synthesis

General Characteristics 2-Oxygenated indoles can be synthesized from the corresponding secondary aryl amines and bisulfite adduct of glyoxal. General References Hinsberg, O. Ber. Dtsch. Chem. Ges. ...

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