Cornforth Rearrangement

Cornforth Rearrangement

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  • Understanding Property and Mechanism
  • General Characteristics

Oxazole compounds containing a carbonyl group at 4-position are known to undergo thermally driven rearrangement. Thiazoles have the similar property as well.

  • General References

  • Reaction Mechanism

As shown in the above scheme, the formation of ylide intermediate by electrocyclic ring opening has been suggested. (Ref: J. Am. Chem. Soc. 197496, 6148Chem. Ber. 1971104, 1408.)

  • Examples

  • Experimental Procedure

  • Experimental Tips

  • References

  • Related Reactions

  • Related Books

  • External Links

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