Conia-Ene Reaction

Conia-Ene Reaction

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In the Conia-ene reaction, the enol and the alkene or alkyne parts of an unsaturated carbonyl compound react and undergo intramolecular cyclization.

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In 2004, Toste reported the gold-catalyzed Conia-ene type reaction of β-ketoesters containing unactivated alkyne.[1] The enantioselective version of this reaction using Pd(II)/Yb(III) dual catalyst system was reported a year later.[2] 

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[1] Kennedy-Smith, J. J.; Staben, S. T.; Toste, F. D. J. Am. Chem. Soc2004126, 4526. DOI: 10.1021/ja049487s[2] Corkey, B. K.; Toste, F. D. J. Am. Chem. Soc., 2005127, 17168. DOI: 10.1021/ja055059q

  • Gao, Q.; Zheng, B. -F.; Li, J.-H.; Yang, D. Org. Lett20057, 2185. DOI: 10.1021/ol050532q
  • Corkey, B. K.; Toste, F. D. J. Am. Chem. Soc. 2005127, 17168. DOI: 10.1021/ja055059q
  • Urabe, F.; Nagashima, S.; Takahashi, K.; Ishihara, J.; Hatakeyama, S. J Org Chem 201378, 3847. DOI: 10.1021/jo400263w
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