Tag Archives: cyclization

Conia-Ene Reaction

Conia-Ene Reaction

General Characteristics In the Conia-ene reaction, the enol and the alkene or alkyne parts of an unsaturated carbonyl compound react and undergo intramolecular cyclization. General References ...

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Baldwin’s Rule

Baldwin’s Rule

General Characteristics The rate of ring closing reactions is largely influenced by how easily the orbitals can interact and overlap at the reacting parts of the molecule. The empirical rule that ...

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Thorpe-Ingold Effect

Thorpe-Ingold Effect

General Characteristics The effect of geminal substitution in linear molecules that promotes cyclization is referred to as the Thorpe-Ingold effect (aka. gem-dialkyl effect). General References ...

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