General Characteristics The three component condensation reaction among aldehydes, amines, and phenols is known as the Betti reaction. This reaction is the phenol version of the Mannich reaction. ...
Posts by Category: Reactions
Pinner Reaction
General Characteristics The treatment of nitriles with HCl-anhydrous alcohol generates imidate salts, which can be converted into amidines and orthoesters using amines and alcohols, respectively. The ...
Hell-Volhard-Zelinsky Reaction
General Characteristics The classical method to convert carboxylic acids into α-haloacyl halides using phosphorus(III) halide is known as the Hell-Volhard-Zelinsky reaction. General References Hell, ...
Norrish Reaction
General Characteristics Upon photo-irradiation, carbonyl compounds undergo carbon-carbon bond cleavage reactions via biradical intermediates. The first type involves the formation of acyl radicals ...
de Mayo Reaction
General Characteristics In the de Mayo reaction, 1,3-dicarboyl compounds and alkenes undergo photo-activated [2+2] cycloaddition. The subsequent ring opening gives 1,5-dicarbonyl products. General ...
Cornforth Rearrangement
General Characteristics Oxazole compounds containing a carbonyl group at 4-position are known to undergo thermally driven rearrangement. Thiazoles have the similar property as well. General ...
Reductvie Desulfurization
General Characteristics Thioethers and thioacetals can be reductively desulfurized by treating them with Raney nickel. The reduction of the latter is a common way to deoxygenate carbonyl groups. ...
Blaise Reaction
General Characteristics In the Blaise reaction, nitriles and zinc-enolates (prepared from zinc and α-haloesters) react to give β-enaminoesters or β-ketoesters. General References Blaise, E. E. Compt. ...
Synthesis of N-Oxide
General Characteristics Amines are susceptible to oxidation. Tertiary amines are oxidized to give N-oxides. Secondary amines having proton(s) at the α-position are oxidized to nitrones. The ...
