Posts by Category: Reactions

AjiPhase Peptide Synthesis

AjiPhase Peptide Synthesis

General Characteristics The advantages of liquid-phase peptide synthesis (LPPS) over solid-phase synthesis (SPPS) include the use of reduced reagents and solvents and the ease of scaling up. The main ...

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Mander’s Reagent

Mander’s Reagent

General Characteristics Methyl cyanoformate, also known as Mander’s reagent, is used to introduce a methoxycarbonyl group to metal enolates for the synthesis of β-ketoesters. Compared with ...

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RAFT Polymerization

RAFT Polymerization

General Characteristics RAFT (Reversible Addition-Fragmentation Chain Transfer) is a type of controlled living radical polymerization methods. By using thiocarbonyl compounds as the chian transfer ...

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Neighboring Group Participation

Neighboring Group Participation

General Characteristics When the functional group(s) located near the reaction center directly influences the reactivity or selectivity of a given reaction, the effect is referred to as neighboring ...

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Zincke Aldehyde

Zincke Aldehyde

General Characteristics Upon nucleophilic attack by secondary amines, 1-(2,4-dinitrophenyl)pyridinium chloride (the Zincke salt) opens up to give 5-aminopenta-2,4-dienal (the Zincke aldehyde). ...

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Clauson-Kaas Pyrrole Synthesis

Clauson-Kaas Pyrrole Synthesis

General Characteristics Pyrroles can be synthesized by the condensation of 2,5-dialkoxytetrahydrofurans with primary amines. General References Clauson-Kaas, N. Acta Chem. Scand. 1952, 6, 667. Josey, ...

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Danishefsky-Kitahara Diene

Danishefsky-Kitahara Diene

General Characteristics trans-1-Methoxy-3-trimethylsiloxy-1,3-butadiene is commonly called the Danishefsky-Kitahara diene (or simply Danishefsky diene). The high HOMO energy level resulting from two ...

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Catellani Reaction

Catellani Reaction

General Characteristics The Catellani reaction is a type of three component reaction in which the Mizoroki-Heck reaction and ortho C-H alkylation with alkyl halide occur concomitantly in the presence ...

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Markovnikov’s Rule

Markovnikov’s Rule

General Characteristics In electrophilic addition reactions of alkenes, the electrophiles (electronically positive atoms or groups) generally bond with the carbon that has more hydrogen atoms. This ...

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