Clauson-Kaas Pyrrole Synthesis

• General Characteristics

Pyrroles can be synthesized by the condensation of 2,5-dialkoxytetrahydrofurans with primary amines.

• General References

• Clauson-Kaas, N. Acta Chem. Scand. 1952, 6, 667.
• Josey, A. D.; Jenner, E. L. J. Org. Chem. 1962, 27, 2466. DOI: 10.1021/jo01054a042
• Patterson, J. M. Synthesis 1976, 281. DOI: 10.1021/jo01054a042

• History

This protocol was reported by the Danish chemist Niels Clauson-Kaas in 1952.

• Reaction Mechanism

• Examples

• Experimental Procedure

• Experimental Tips

• References

• Related Reactions

• Knorr Pyrrole Synthesis
• Barton-Zard Pyrrole Synthesis
• Paal-Knorr Pyrrole Synthesis
• Piloty-Robinson Pyrrole Synthesis
• Hantzsch Pyrrole Synthesis

• Related Books

• External Links

synthesis of pyrrole from dialkoxytetrahydrofuran