Clauson-Kaas Pyrrole Synthesis

Clauson-Kaas Pyrrole Synthesis

15 May, 2016 / by / in Reactions
5639
Overall Score4
  • Generality
  • Reagent Availability
  • Experimental User Friendliness

  • General Characteristics

Pyrroles can be synthesized by the condensation of 2,5-dialkoxytetrahydrofurans with primary amines.

  • General References

  • Clauson-Kaas, N. Acta Chem. Scand. 1952, 6, 667.
  • Josey, A. D.; Jenner, E. L. J. Org. Chem. 1962, 27, 2466. DOI: 10.1021/jo01054a042
  • Patterson, J. M. Synthesis 1976, 281. DOI: 10.1021/jo01054a042

  • History

This protocol was reported by the Danish chemist Niels Clauson-Kaas in 1952.

Niels Clauson-Kaas

  • Reaction Mechanism

Clauson_Kaas_Pyrrole_2.gif

  • Examples

  • Experimental Procedure

  • Experimental Tips

  • References

  • Related Reactions

  • Related Books

  • External Links