Posts by Category: Reactions

Edman Degradation

Edman Degradation

General Characteristics The Edman degradation is a way to determine the primary structure of peptides. Phenyl isocyanate reacts with the N-terminus amino acid residue and only that residue is cleaved ...

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Barton Vinyl Iodide Synthesis

Barton Vinyl Iodide Synthesis

General Characteristics Hydrazones can be converted into vinyl iodides using molecular iodine under mild conditions. Vinyl selenides can be synthesized as well in similar manner using reagents such ...

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Charette Asymmetric Cyclopropanation

Charette Asymmetric Cyclopropanation

General Characteristics The Simmons-Smith cyclopropanation can be rendered asymmetric by using the chiral boronic acid ester as a reagent. An allylic hydroxyl group is needed in substrates as a ...

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Samarium(II) Iodide

Samarium(II) Iodide

General Characteristics Samarium(II) iodide (SmI2) is a mild one-electron reducing agent used for various reductive reactions of carbonyl compounds, organic halides, and electron deficient olefins. ...

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Prato Reaction

Prato Reaction

General Characteristics The derivatization of fullerenes using azomethine ylides via 1,3-dipoloar cycloaddition was developed by Prato. This methodology is applicable to carbon nanotubes as well. ...

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Rosenmund-von Braun Reaction

Rosenmund-von Braun Reaction

General Characteristics Aromatic nitriles can be synthesized from the corresponding aryl halides using copper(I) cyanide. The reaction tends to require high temperature conditions but is ...

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Thiol-ene Reaction

Thiol-ene Reaction

General Characteristics Thiols and alkenes undergo free-radical mediated S-C bond formation known as thiol-ene reaction. Thanks to its high chemoselectivity and functional group tolerance, it is ...

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Thorpe-Ingold Effect

Thorpe-Ingold Effect

General Characteristics The effect of geminal substitution in linear molecules that promotes cyclization is referred to as the Thorpe-Ingold effect (aka. gem-dialkyl effect). General References ...

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Bioconjugation

Bioconjugation

General Characteristics Bioconjugation is a process of covalently functionalizing biological molecules. It is most relevant to protein chemistry and is one of the newest topics in reaction ...

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Deuterium Labeling Reaction

Deuterium Labeling Reaction

General Characteristics The exchange of hydrogen with its isotope deuterium has a wide range of useful applications. The underlying principle is that while replacement of hydrogen with deuterium ...

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