General Characteristics The Minisci reaction allows for the direct functionalization of electron deficient hetero aromatic rings with carbon radicals. The radical precursor is most commonly the ...
Posts by Category: Reactions
Di-π-methane Rearrangement
General Characteristics 1,4-Dienes undergo light-promoted rearrangement to give vinylcyclopropanes. The scope of this reaction includes dienes containing heteroatoms such as oxygen and nitrogen and ...
Norrish-Yang Reaction
General Characteristics In the Norrish-Yang reaction, the C-H bond at the γ-position of ketones is homolytically cleaved by photo-irradiation and the ensuing rearrangement leads to the formation of ...
Aromatic Meta Photocycloaddition
General Characteristics Aromatic rings and alkenes undergo [3+2] cycloaddition under photo-irradiated conditions. This reaction provides complex fused ring skeletons that are otherwise difficult to ...
Edman Degradation
General Characteristics The Edman degradation is a way to determine the primary structure of peptides. Phenyl isocyanate reacts with the N-terminus amino acid residue and only that residue is cleaved ...
Barton Vinyl Iodide Synthesis
General Characteristics Hydrazones can be converted into vinyl iodides using molecular iodine under mild conditions. Vinyl selenides can be synthesized as well in similar manner using reagents such ...
Charette Asymmetric Cyclopropanation
General Characteristics The Simmons-Smith cyclopropanation can be rendered asymmetric by using the chiral boronic acid ester as a reagent. An allylic hydroxyl group is needed in substrates as a ...
Samarium(II) Iodide
General Characteristics Samarium(II) iodide (SmI2) is a mild one-electron reducing agent used for various reductive reactions of carbonyl compounds, organic halides, and electron deficient olefins. ...
Prato Reaction
General Characteristics The derivatization of fullerenes using azomethine ylides via 1,3-dipoloar cycloaddition was developed by Prato. This methodology is applicable to carbon nanotubes as well. ...
Rosenmund-von Braun Reaction
General Characteristics Aromatic nitriles can be synthesized from the corresponding aryl halides using copper(I) cyanide. The reaction tends to require high temperature conditions but is ...