Zinc Borohydride

Zinc Borohydride

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Zinc borohydride (Zn(BH4)2) is prepared from ZnCl2 and NaBH4. In addition to being used for 1,2-reduction of α,β-unsaturated carbonyl compounds, it can selectively reduce aldehydes in the presence of ketones, and isolated ketones over conjugated ketones.

Highly diastereoselective reduction of chelating substrates (such as β-hydroxyketones) is also possible.

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  • Reaction Mechanism

The diastereoselectivity in the reduction of chelating substrates can be explained by the general chelation model.

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