Bohlmann-Rahtz Pyridine Synthesis

Bohlmann-Rahtz Pyridine Synthesis

  • General Characteristics

Pyridines can be synthesized by condensation of appropriately substituted enamines and ethynyl ketones, which proceeds via aminodiene intermediates.

  • General References


  • Reaction Mechanism


  • Examples

De novo construction of the pyridine ring in the total synthesis of promothiocin A.[1]


  • Experimental Procedure

  • Experimental Tips

  • References

Bagley, M. C.; Bashford, K. E.; Hesketh, C. L.; Moody, C. J. J. Am. Chem. Soc. 2000, 122, 3301. DOI: 10.1021/ja994247b

  • Related Reactions

  • Related Books

  • External Links