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General Characteristics
Pyridines can be synthesized by condensation of appropriately substituted enamines and ethynyl ketones, which proceeds via aminodiene intermediates.
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General References
- Bohlman, F.; Rahtz, D. Chem. Ber. 1957, 90, 2265. DOI: 10.1002/cber.19570901021
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- Bagley, M. C.; Glover, C. Synlett 2007, 2459. DOI: 10.1055/s-2007-986674
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Reaction Mechanism
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Examples
De novo construction of the pyridine ring in the total synthesis of promothiocin A.[1]
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Experimental Procedure
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Experimental Tips
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References
Bagley, M. C.; Bashford, K. E.; Hesketh, C. L.; Moody, C. J. J. Am. Chem. Soc. 2000, 122, 3301. DOI: 10.1021/ja994247b
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Related Reactions
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Related Books
[amazonjs asin=”3527327479″ locale=”US” title=”The Chemistry of Heterocycles: Structures, Reactions, Synthesis, and Applications 3rd, Completely Revised and Enlarged Edition”]
[amazonjs asin=”0471302155″ locale=”US” title=”Name Reactions in Heterocyclic Chemistry”]
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External Links
- Bohlmann-Rahtz Pyridine Synthesis (organic-chemistry.org)
- Bohlmann-Rahtz Pyridine Synthesis (SynArchive)