Paal-Knorr Thiophene Synthesis

Paal-Knorr Thiophene Synthesis

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  • General Characteristics

The condensation of 1,4-dicarbonyl compounds with sulfur sources gives thiophenes. Phosphorus pentasulfide (P4S10) and the Lawesson’s reagent are typically used as the sulfur source.

  • General References

  • Reaction Mechanism

  • Examples

  • Experimental Procedure

  • Experimental Tips

The experiment should be carried out carefully since the reaction generates highly toxic hydrogen sulfide gas.

  • References

  • Related Reactions

Paal-Knorr Furan Synthesis

 Paal-Knorr Pyrrole Synthesis

Hinsberg Thiophene Synthesis

Gewald Thiophene Synthesis

  • Related Books

  • External Links

Thiophene – Wikipedia

Paal thiophene synthesis (

Synthesis of thiophene (

Paal-Knorr Synthtesis – Wikipedia

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