Overall Score4
- Generality
- Reagent Availability
- Experimental User Friendliness
-
General Characteristics
In the presence of copper catalysts, nitrones and terminal alkynes undergo 1,3-dipolar cycloaddition to give β-lactams.
-
General References
- Kinugasa, M.; Hashimoto, S. J. Chem. Soc., Chem. Commun.1972, 466. doi:10.1039/C39720000466
- Stanley, L. M.; Sibi, M. P. Chem. Rev. 2008, 108, 2887. doi:10.1021/cr078371m
-
Reaction Mechanism
The in situ-formed copper acetylide presumably undergoes 1,3-dipolar cycloaddition with nitrone.
-
Examples
-
Experimental Procedure
-
Experimental Tips
-
References
-
Related Reactions
-
Related Books
-
External Links