General Characteristics The oxidation of alcohols based on the dimethylsulfide-NCS system is known as the Corey-Kim oxidation. The oxidation of primary alcohols stops at the aldehyde oxidation state. ...
Posts by Category: Reactions
Michaelis-Arbuzov Reaction
General Characteristics The reaction between phosphorous acid esters (phosphites) and alkyl halides gives phosphonic acid esters. When the phosphite and the alkyl halide have the same alkyl group, ...
Reformatsky Reaction
General Characteristics In the Reformatsky reaction, the enolates formed from α-haloesters and zinc metal add to aldehydes and ketones. Zinc enolates are less basic, less reactive, and thus more ...
Mukaiyama Oxidation
General Characteristics The Swern oxidation is relatively clean and practical but also associated with such problems as the generation of carbon monoxide and dimethylsulfide and the requirement of ...
Corey-Bakshi-Shibata (CBS) Reduction
General Characteristics The asymmetric reduction of ketones catalyzed by the chiral oxazaborolidine (derived from proline) is called the Corey-Bakshi-Shibata (CBS) reduction. The reaction has a wide ...
Barton-McCombie Deoxygenation
General Characteristics The free radical-mediated deoxygenation of alcohol compounds after the formation of thiocarbonyl intermediates is known as the Barton-MacCombie deoxygenation. This reaction is ...
Ruthenium Tetroxide (RuO4)
General Characteristics Ruthenium tetroxide is a very strong oxidizing agent capable of even oxidative cleavage of benzene rings and olefins. The reagent can therefore be thought of as an alternative ...
Takai-Uchimoto Olefination
General Characteristics -The synthesis of alkenyl halides from aldehydes using the gem-dichromium reagent prepared from haloform (CHX3) and CrCl2 is known as the Takai-Uchimoto reaction. Mild ...
Sharpless Asymmetric Dihydroxylation (Sharpless AD)
General Characteristics -Sharpless developed chiral ligands ((DHQD)2PHAL or (DHQ)2PHAL) derived from cinchona alkaloids (quinidine, quinine) for the practical osmium tetroxide-catalyzed asymmetric ...
Kumada-Tamao-Corriu Cross Coupling
General Characteristics The palladium- or nickel-catalyzed cross coupling between aryl halides/triflates and Grignard reagents is known as the Kumada-Tamao-Corriu reaction. The Kumada-Tamao-Corriu ...