General Characteristics The reaction of aldehydes or ketones with ammonia equivalents or primary or secondary amines in the presence of hydride reducing agents gives alkylated amines. The reductive ...
Posts by Category: Reactions
Knoevenagel Condensation
General Characteristics Activated methylene compounds condense with aldehydes and ketones to give substituted alkenes. Piperidine is generally used as the catalyst. Nitromethane also undergoes ...
Wolff-Kishner Reduction
General Characteristics The deoxygenation of carbonyl compounds through hydrazone formation is known as the Wolff-Kishner reduction. Heating a mixture containing an aldehyde or a ketone, hydrazine, ...
Prilezhaev Epoxidation
General Characteristics The oxidation of olefins to epoxides using peracids is known as the Prilezhaev epoxidation. m-Chloroperoxybenzoic acid (mCPBA) in particular is used often in laboratories ...
Birch Reduction
General Characteristics -Aromatic compounds are reduced to 1,4-cyclohexadienes by treatment with alkali matals (Li, Na, or K) or alkaline earth metals (Ca or Mg) dissolved in a mixed solvent of ...
Parikh-Doering Oxidation
General Characteristics The Parikh-Doering oxidation uses SO3•Py (a solid reagent that can be handled easily) as the activator of DMSO. This reaction is especially effective for the oxidation of ...
PCC/PDC Oxidation
General Characteristics The oxidation of alcohols by PCC (Pyridinium Chlorochromate) or PDC (Pyridinium Dichromate) works under mild conditions and can be used for compounds containing unstable ...
Protection of 1,2-/1,3-Diols
General Characteristics 1,2- and 1,3-diols are generally protected as 5- or 6-membered cyclic acetal compounds. General References ・Ley, S. V.; Baeschlin, D. K.; Dixon, D. J.; Foster, A. C.; ...
Corey-Nicolaou Macrolactonization
General Characteristics The macrolactonization reaction using 2,2’-dipyridyldisulfide and triphenylphosphine is known as the Corey-Nicolaou reaction. The cyclization step usually requires a high ...
Reduction with Metal Hydrides
General Characteristics Carbonyl compounds are reduced by metal hydride reagents to give alcohols. A number of reagents with various reducing strengths and properties are known. The metal hydride ...