Posts by Category: Reactions

Borch Reductive Amination

Borch Reductive Amination

General Characteristics The reaction of aldehydes or ketones with ammonia equivalents or primary or secondary amines in the presence of hydride reducing agents gives alkylated amines. The reductive ...

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Knoevenagel Condensation

Knoevenagel Condensation

General Characteristics Activated methylene compounds condense with aldehydes and ketones to give substituted alkenes. Piperidine is generally used as the catalyst. Nitromethane also undergoes ...

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Wolff-Kishner Reduction

Wolff-Kishner Reduction

General Characteristics The deoxygenation of carbonyl compounds through hydrazone formation is known as the Wolff-Kishner reduction. Heating a mixture containing an aldehyde or a ketone, hydrazine, ...

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Prilezhaev Epoxidation

Prilezhaev Epoxidation

General Characteristics The oxidation of olefins to epoxides using peracids is known as the Prilezhaev epoxidation. m-Chloroperoxybenzoic acid (mCPBA) in particular is used often in laboratories ...

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Birch Reduction

Birch Reduction

General Characteristics -Aromatic compounds are reduced to 1,4-cyclohexadienes by treatment with alkali matals (Li, Na, or K) or alkaline earth metals (Ca or Mg) dissolved in a mixed solvent of ...

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Parikh-Doering Oxidation

Parikh-Doering Oxidation

General Characteristics The Parikh-Doering oxidation uses SO3•Py (a solid reagent that can be handled easily) as the activator of DMSO. This reaction is especially effective for the oxidation of ...

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PCC/PDC Oxidation

PCC/PDC Oxidation

General Characteristics The oxidation of alcohols by PCC (Pyridinium Chlorochromate) or PDC (Pyridinium Dichromate) works under mild conditions and can be used for compounds containing unstable ...

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Protection of 1,2-/1,3-Diols

Protection of 1,2-/1,3-Diols

General Characteristics 1,2- and 1,3-diols are generally protected as 5- or 6-membered cyclic acetal compounds.   General References ・Ley, S. V.; Baeschlin, D. K.; Dixon, D. J.; Foster, A. C.; ...

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Corey-Nicolaou Macrolactonization

Corey-Nicolaou Macrolactonization

General Characteristics The macrolactonization reaction using 2,2’-dipyridyldisulfide and triphenylphosphine is known as the Corey-Nicolaou reaction. The cyclization step usually requires a high ...

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Reduction with Metal Hydrides

Reduction with Metal Hydrides

General Characteristics Carbonyl compounds are reduced by metal hydride reagents to give alcohols. A number of reagents with various reducing strengths and properties are known. The metal hydride ...

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