Rhodium-Catalyzed Three-Component Cross-Addition of Silylacetylenes, Alkynyl Esters, and Electron-Deficient Alkenes or Isocyanates

Rhodium-Catalyzed Three-Component Cross-Addition of Silylacetylenes, Alkynyl Esters, and Electron-Deficient Alkenes or Isocyanates

Hoshino, Y.; Shibata, Yu.; Tanaka, K.; Angew. Chem. Int. Ed. 2012, Early View.

DOI: 10.1002/anie.201204646

’Rh’oad crossing: A cationic RhI/(cod)2 complex catalyzes the chemo-, regio-, and stereoselective title reaction with electron-deficient alkenes leading to substituted 1,3-dienes. The analogous three-component cross-addition involving isocyanates instead of alkenes has also been developed.

kentanaka

Prof. Tanaka form Tokyo University of Agriculture and Technology has been reported the unprecedented transition- metal-catalyzed chemo-, regio-, and stereoselective three- component cross-addition of silylacetylenes, alkynes, and alkenes, thus leading to substituted 1,3-dienes.

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