Decarbonylative C–H Coupling of Azoles and Aryl Esters: Unprecedented Nickel Catalysis and Application to the Synthesis of Muscoride A

Decarbonylative C–H Coupling of Azoles and Aryl Esters: Unprecedented Nickel Catalysis and Application to the Synthesis of Muscoride A

22 August, 2012 / by / in OrganicChem, Papers
4706

 

Amaike, K.; Muto, K.;  Yamaguchi, J.;  Itami, K. J. Am. Chem. Soc., 2012, 134 , 13573–13576.

DOI: 10.1021/ja306062c

A nickel-catalyzed decarbonylative C–H biaryl coupling of azoles and aryl esters is described. The newly developed catalytic system does not require the use of expensive metal catalysts or silver- or copper-based stoichiometric oxidants. We have successfully applied this new C–H arylation reaction to a convergent formal synthesis of muscoride A.

nagoya

Prof. Itami from Nagoya University has been reported novel nickel-catalyazed C–H coupling of azoles and aryl esters. This novel reaction adds another possibility to the existing toolboxof the synthetic chemist in the construction of biaryl molecules. Finally, the method is elegantly applied to the synthesis of muscoride A.

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