General Characteristics Reactions such as SN2 substitution involve deprotonation by strong bases and combining the resulting anions with electrophiles. These reactions often necessitate the use of ...
Posts by Category: Reactions
Petasis-Ferrier Rearrangement
General Characteristics The Lewis acid-promoted rearrangement of enol acetals to cyclic ethers, which involves an oxygen-to-carbon transposition, is known as the Petasis-Ferrier rearrangement. This ...
Ferrier Rearrangement
General Characteristics The introduction of nucleophilic groups to the 1-position of 1,2-glycals by an allylic substitution is called the Ferrier reaction. This reaction is referred to as the “Type ...
Ramberg-Backlund Rearrangement
General Characteristics The basic treatment of α-halogenated sulfones leads to the formation of alkenes with the elimination of sulfur dioxide. This reaction is called the Ramberg-Backlund reaction ...
Benzidine Rearrangement
General Characteristics Under acidic conditions, 1,2-diphenylhydrazines are known to rearrange into 4,4’-diaminobiphenyls (benzidines). General References Hofmann, A. W. Proc. Roy. Soc. London ...
Akiyama-Terada Catalyst
General Characteristics The phosphoric acids containing an appropriately substituted BINOL backbone function as chiral Brønsted acid catalysts that can promote a wide range of stereoselective ...
Fujiwara-Moritani Reaction
General Characteristics The direct coupling between unsubstituted aromatic rings and olefins in the presence of palladium catalysts is called the Fujiwara-Moritani reaction. This reaction is one of ...
Ireland-Claisen Rearrangement
General Characteristics The Ireland-Claisen rearrangement is a version of the Claisen rearrangement in which ketene silyl acetals (prepared from allyl esters) undergo [3,3]-sigmatropic rearrangement ...
Overman Rearrangement
General Characteristics The trichloroacetimidates of allylic alcohols, prepared using trichloroacetonitrile, undergo thermal or catalyzed [3,3]-sigmatropic rearrangement, which is referred to as the ...
Aza-Cope Rearrangement
General Characteristics Nitrogen-containing 1,5-dienes undergo [3,3]-sigmatropic rearrangement just like the Cope rearrangement of 1,5-dienes. Among these so-called aza-Cope rearrangements, the 3-aza ...