Posts by Category: Reactions

Ferrier Rearrangement

Ferrier Rearrangement

General Characteristics The introduction of nucleophilic groups to the 1-position of 1,2-glycals by an allylic substitution is called the Ferrier reaction. This reaction is referred to as the “Type ...

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Ramberg-Backlund Rearrangement

Ramberg-Backlund Rearrangement

General Characteristics The basic treatment of α-halogenated sulfones leads to the formation of alkenes with the elimination of sulfur dioxide. This reaction is called the Ramberg-Backlund reaction ...

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Benzidine Rearrangement

Benzidine Rearrangement

General Characteristics Under acidic conditions, 1,2-diphenylhydrazines are known to rearrange into 4,4’-diaminobiphenyls (benzidines). General References Hofmann, A. W. Proc. Roy. Soc. London ...

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Akiyama-Terada Catalyst

Akiyama-Terada Catalyst

General Characteristics The phosphoric acids containing an appropriately substituted BINOL backbone function as chiral Brønsted acid catalysts that can promote a wide range of stereoselective ...

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Fujiwara-Moritani Reaction

Fujiwara-Moritani Reaction

General Characteristics The direct coupling between unsubstituted aromatic rings and olefins in the presence of palladium catalysts is called the Fujiwara-Moritani reaction. This reaction is one of ...

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Ireland-Claisen Rearrangement

Ireland-Claisen Rearrangement

General Characteristics The Ireland-Claisen rearrangement is a version of the Claisen rearrangement in which ketene silyl acetals (prepared from allyl esters) undergo [3,3]-sigmatropic rearrangement ...

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Overman Rearrangement

Overman Rearrangement

General Characteristics The trichloroacetimidates of allylic alcohols, prepared using trichloroacetonitrile, undergo thermal or catalyzed [3,3]-sigmatropic rearrangement, which is referred to as the ...

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Aza-Cope Rearrangement

Aza-Cope Rearrangement

General Characteristics Nitrogen-containing 1,5-dienes undergo [3,3]-sigmatropic rearrangement just like the Cope rearrangement of 1,5-dienes. Among these so-called aza-Cope rearrangements, the 3-aza ...

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Diazomethane

Diazomethane

General Characteristics Diazomethane (CH2N2) is the simplest example of diazo compounds. It is traditionally used to synthesize methyl esters of carboxylic acids. This methyl ester formation is very ...

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Du Bois Amination

Du Bois Amination

General Characteristics The direct amination of unactivated C-H bonds utilizing metal nitrenoids, especially with Rh-catalysis, became a practical synthetic option in the early 2000’s. This reaction ...

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