Monthly Archives: March 2014

Carbamate Protective Groups

Carbamate Protective Groups

General Characteristics In order to tame the basicity and the high reactivity of amines during multi-step synthesis, it is common to protect them with electron-withdrawing functional groups. ...

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Acetal Protective Groups

Acetal Protective Groups

General Characteristics Alcohols can be protected as acetals against reductive and basic conditions. Oxygen-based acetals are also stable under oxidizing conditions. Deprotection is usually done ...

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Olefin Metathesis

Olefin Metathesis

General Characteristics In the presence of a metal alkylidene catalyst, two olefins combine and redistribute their fragments to give a new pair of olefins. Olefin metathesis is fundamentally an ...

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