Monthly Archives: March 2014

Benzyl (Bn) Protective Group

Benzyl (Bn) Protective Group

General Characteristics -Benzyl group (Bn) is stable towards both acids and bases and is a highly general protecting group. -Base sensitive compounds can be protected using BnOC(=NH)CCl3 under acidic ...

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Silyl Protective Groups

Silyl Protective Groups

General Characteristics -Serving as effective protective groups for alcohols, silyl ethers are used extensively in laboratory scale synthesis. -At least two of the three R’ groups are the same group, ...

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Minisci Reaction

Minisci Reaction

Characteristics   Literature reference ・Minisci, F.; Bernardi, R.; Bertini, F.; Galli, R.; Perchinummo, M. Tetrahedron 1971, 27, 3575. DOI:10.1016/S0040-4020(01)97768-3 ・Minisci, F.; Vismara, ...

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Barry M. Trost

Barry M. Trost

Barry M. Trost (born in 1941) is an American organic chemist, Tamaki Professor of Humanities and Sciences in the chemistry department at Stanford University. He has made great contributions to the ...

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Thorpe-Ziegler Reaction

Thorpe-Ziegler Reaction

Characteristics The reaction between a nitrile and an alkoxide base leads to the formation of a β-iminonitrile from which an α-cyanoketone is obtained by mild acid hydrolysis. This reaction is ...

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Hydration of Alkyne

Hydration of Alkyne

Characteristics Hydration of alkynes is simply the addition of H2O in the presence of Lewis acids. The hydration of alkynes has been extensively studied for more than 100 years. This reation allows ...

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