General Characteristics -Benzyl group (Bn) is stable towards both acids and bases and is a highly general protecting group. -Base sensitive compounds can be protected using BnOC(=NH)CCl3 under acidic ...
Monthly Archives: March 2014
Silyl Protective Groups
General Characteristics -Serving as effective protective groups for alcohols, silyl ethers are used extensively in laboratory scale synthesis. -At least two of the three R’ groups are the same group, ...
Minisci Reaction
Characteristics Literature reference ・Minisci, F.; Bernardi, R.; Bertini, F.; Galli, R.; Perchinummo, M. Tetrahedron 1971, 27, 3575. DOI:10.1016/S0040-4020(01)97768-3 ・Minisci, F.; Vismara, ...
Barry M. Trost
Barry M. Trost (born in 1941) is an American organic chemist, Tamaki Professor of Humanities and Sciences in the chemistry department at Stanford University. He has made great contributions to the ...
Thorpe-Ziegler Reaction
Characteristics The reaction between a nitrile and an alkoxide base leads to the formation of a β-iminonitrile from which an α-cyanoketone is obtained by mild acid hydrolysis. This reaction is ...
Direct Hydroboration of B=B Bonds: A Mild Strategy for the Proliferation of B=B Bonds
Braunschweig, H.; Dewhurst, R. D.; Hcrl, C.; Phukan, A. K.; Pinzner, F.; Ullrich, S. Angew. Chem. Int. Ed. 53, 2014. Early View. DOI: 10.1002/anie.201309325 Synthetic access to electron-precise boron ...
Inorganic-Base-Mediated Hydroamination of Alkenyl Oximes for the Synthesis of Cyclic Nitrones
Peng, X.; Tong, M. K. B.; Hirao,H.; Chiba, S. Angew. Chem. Int. Ed. 53, 2014. 1959. DOI: 10.1002/anie.201308617 A method based on hydroamination mediated by inorganic base was developed for the ...
Oxidant-Free Conversion of Cyclic Amines to Lactams and H2 Using Water As the Oxygen Atom Source
Khusnutdinova, J. R.; Ben-David, Y.; Milstein, D. J. Am. Chem. Soc. 136, 2014. 2998. DOI: 10.1021/ja500026m Direct conversion of cyclic amines to lactams utilizing water as the only reagent is ...
Hydration of Alkyne
Characteristics Hydration of alkynes is simply the addition of H2O in the presence of Lewis acids. The hydration of alkynes has been extensively studied for more than 100 years. This reation allows ...