Characteristics Trimethylenemethane (TMM) [3 + 2] cycloadditions provide direct routes to functionalized cyclopentanes. This reaction has been shown to be a highly chemo-, regio-, and ...
Posts by Category: Reactions
Negishi Carbometalation
Characteristics Ngishi carbometalation is shown to involve one-step syn-addition of a Me–Zr bond to terminal alkynes in an anti-Markovnikov manner followed by Zr-to-Al transmetalation on the ...
Electrophilic Trifluoromethylation
Characteristics Efficient transfer of the trifluoromethyl group from a reagent to a target molecule is key for the reaction, and the reagents are classified according to their radical, nucleophilic ...
Crabbe Allene Synthesis
Characteristics Crabbe allene synthesis (Crabbe homologation) is Cu-cataylzed synthesis of terminal allene compounds via homologation of acetylene precursors in the presence of diisopropylamine and ...
MIDA boronate
Characteristics N-methyliminodiacetic acid (MIDA) is very useful protecting group for boronic acid and forms stable (more stable that the free acid) boronates which are readily prepared from the ...
Amii Trifluoromethylation
Characteristics Amii trifluoromethylation is a the synthesis of trifluoromethylarenes from aryl/heteroaryliodides with CF3SiEt3 by Cu-catalsis. Selective introduction of trifluoromethyl ...
Merrifield Solid-Phase Peptide Synthesis
Characteristics A protein consists of one peptide folded in a particular way, or several peptides folded together. Such peptides are synthesised very rapidly within living cells, but until recently ...
Kharasch-Sosnovsky Oxidation
Characteristics Kharasch and Sosnovsky reported the allylic oxidation of alkenes to give racemic allylic benzoate’s. This could be achieved efficiently using a tert-butyl perester as the ...
Kharasch Addition
Characteristics Kharasch addition is the addition of polyhalogenated compounds to alkenes. This reaction was first reported in the 1940s by Kharasch[a] and today is known as Kharasch addition or ...
C-H Oxidation with NHPI Catalyst
Characteristics N-hydroxyphthalimide (NHPI) and related compounds have been revealed to be efficient organocatalysts for free-radical processes and have found ample application in promoting the ...