Characteristics Literature reference ・Minisci, F.; Bernardi, R.; Bertini, F.; Galli, R.; Perchinummo, M. Tetrahedron 1971, 27, 3575. DOI:10.1016/S0040-4020(01)97768-3 ・Minisci, F.; Vismara, ...
Posts by Category: Reactions
Thorpe-Ziegler Reaction
Characteristics The reaction between a nitrile and an alkoxide base leads to the formation of a β-iminonitrile from which an α-cyanoketone is obtained by mild acid hydrolysis. This reaction is ...
Hydration of Alkyne
Characteristics Hydration of alkynes is simply the addition of H2O in the presence of Lewis acids. The hydration of alkynes has been extensively studied for more than 100 years. This reation allows ...
Selective Transformation with Tin Acetal
Characteristics Typically, the 1,2-diol is treated with Bu2SnX, where X = O or (OMe), with removal (azeotropic or desiccant) of either H2O or MeOH to afford the requisite stannylidenes (“tin ...
Ichikawa Allylcyanate Rearrangement
Characteristics Ichikawa Allylcyanate rearrangement is [3.3] sigmatropic rearrangement of allyl cyanates to isocyanate. The rearrangement begins with dehydration of allyl carbamate by Appel ...
Singlet Oxygen
Characteristics Since molecular oxygen exists in a triplet ground state (3O2),the spin conservation rule restricts its transforma- tions to radical-type reactions, which are normally quite ...
1,3-Dipolar Cycloaddition of Nitrile Oxide
Characteristics Nitrile oxides, R-C≡N+-O- are organic compounds which contain a monovalent functional group -CNO, which bound directly to a carbon atom of the organic moiety of a molecule. Most ...
1,3-Dipolar Cycloaddition of Nitrone
Characteristics The 1,3-dipolar cycloaddition of nitrones, a kind of 1,3-dipole to unsaturated (C–C double or triple bond) compounds is one of the useful synthetic method for preparing isoxazole, ...
Trimethylenemethane(TMM) Cycloaddition
Characteristics Trimethylenemethane (TMM) [3 + 2] cycloadditions provide direct routes to functionalized cyclopentanes. This reaction has been shown to be a highly chemo-, regio-, and ...
Negishi Carbometalation
Characteristics Ngishi carbometalation is shown to involve one-step syn-addition of a Me–Zr bond to terminal alkynes in an anti-Markovnikov manner followed by Zr-to-Al transmetalation on the ...