General Characteristics -The acylation of aromatic rings using acyl halides or acid anhydrides mediated by Lewis acids is called the Friedel-Crafts acylation. Arenes substituted with electron ...
Monthly Archives: April 2014
Samuel J. Danishefsky
Samuel J. Danishefsky (born 1936, Bayonne, NJ) is synthetic organic chemist who accomplished in natural products total synthesis and pioneer for chemical synthesis of carbohydrates for the ...
Vilsmeier-Haack Reaction
General Characteristics The Vilsmeier-Haack reaction is a common method to introduce a formyl group into electron rich aromatic compounds. It is also applicable to electron rich alkenes. The ...
Williamson Ether Synthesis
General Characteristics -The synthesis of unsymmetrical ethers by SN2 displacement of alkyl halides by alkoxides is called the Williamson ether synthesis. The reaction works best when the R group is ...
Installing artificial nucleotide bases in DNA
[su_dropcap] It[/su_dropcap] is common knowledge that genetic information of organisms is encoded in DNA in the form of sequential interactions of merely four nucleotide bases, Adenine(A), ...
Aromatic Homologation by Non-Chelate-Assisted RhIII-Catalyzed C–H Functionalization of Arenes with Alkynes
Pham, M. V.; Cramer, N. Angew. Chem. Int. Ed. 2014. Early View. DOI: 10.1002/anie.201310723 Larger condensed arenes are of interest owing to their electro- and photochemical properties. An efficient ...
Roger Kornberg
Roger D. Kornberg (born 1947), biochemist who received the Nobel Prize in Chemistry in 2006 for his research on the molecular basis of eukaryotic transcription. His father, Arthur Kornberg, who won ...
Curtius Rearrangement
General Characteristics -Upon heating, acyl azides undergo rearrangement to give isocyanates with the loss of N2. In the presence of water, the isocyanates are immediately hydrolyzed to give amines ...
Acyl Protective Groups
General Characteristics -Acyl groups are generally stable under acidic and oxidative conditions and deprotected under reductive (DIBAL, LAH, etc.) and basic (NaOH, K2CO3/MeOH etc.) conditions. ...