General Characteristics -The Mannich reaction is a classic example of three-component condensation reactions. -Under acidic conditions, an amine and an aldehyde condense to form an iminium ion, which ...
Monthly Archives: April 2014
Cross Aldol Reaction
General Characteristics -In cross aldol reactions, the donor carbonyl compound is deprotonated completely by a strong base like LDA to preform its metal enolate, which prevents self-condensation upon ...
Buchwald-Hartwig Cross Coupling Reaction
General Characteristics -The palladium-catalyzed cross coupling between aryl halides/triflates and amines/alkoxides is known as the Buchwald-Hartwig reaction. The use of bidentate ligands (e.g. dppf, ...
TPAP (Ley-Griffith) Oxidation
General Characteristics The oxidation of alcohols to aldehydes or ketones can be catalyzed by TPAP (nPr4N+RuO4–; TetraPropylAmmonium Perruthenate) which is air- and moisture-tolerant and also ...