Zárate, C.; Martin, R. J. Am. Chem. Soc. 2014, ASAP. DOI: 10.1021/ja412107b A Ni/Cu-catalyzed silylation of unactivated C–O electrophiles derived from phenols or benzyl alcohols is described. This ...
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Crabbe Allene Synthesis
Characteristics Crabbe allene synthesis (Crabbe homologation) is Cu-cataylzed synthesis of terminal allene compounds via homologation of acetylene precursors in the presence of diisopropylamine and ...
MIDA boronate
Characteristics N-methyliminodiacetic acid (MIDA) is very useful protecting group for boronic acid and forms stable (more stable that the free acid) boronates which are readily prepared from the ...
Amii Trifluoromethylation
Characteristics Amii trifluoromethylation is a the synthesis of trifluoromethylarenes from aryl/heteroaryliodides with CF3SiEt3 by Cu-catalsis. Selective introduction of trifluoromethyl ...
Merrifield Solid-Phase Peptide Synthesis
Characteristics A protein consists of one peptide folded in a particular way, or several peptides folded together. Such peptides are synthesised very rapidly within living cells, but until recently ...
Kharasch-Sosnovsky Oxidation
Characteristics Kharasch and Sosnovsky reported the allylic oxidation of alkenes to give racemic allylic benzoate’s. This could be achieved efficiently using a tert-butyl perester as the ...
Kharasch Addition
Characteristics Kharasch addition is the addition of polyhalogenated compounds to alkenes. This reaction was first reported in the 1940s by Kharasch[a] and today is known as Kharasch addition or ...
Karl Barry Sharpless
Karl Barry Sharpless (born in 1941) is an American chemist who was awarded half the 2001 Nobel Prize in Chemistry for his research into chirally catalysed oxidation reactions. He has discovered and ...
C-H Oxidation with NHPI Catalyst
Characteristics N-hydroxyphthalimide (NHPI) and related compounds have been revealed to be efficient organocatalysts for free-radical processes and have found ample application in promoting the ...