Akira, Suzuki (Born in 1930), is Japanese organic chemist. Suzuki was one of the recipients of Nobel prize in Chemistry 2010, with Richard Heck and Ei-ichi Negishi for their research during the 1960s ...
Monthly Archives: February 2014
Robert B. Merrifield
Robert Bruce Merrifield, (1921-) is an American biochemist who won the 1984 Nobel Prize in chemistry for his method of producing peptides and proteins. He revolutionized the study of these complex ...
Negishi Carbometalation
Characteristics Ngishi carbometalation is shown to involve one-step syn-addition of a Me–Zr bond to terminal alkynes in an anti-Markovnikov manner followed by Zr-to-Al transmetalation on the ...
Electrophilic Trifluoromethylation
Characteristics Efficient transfer of the trifluoromethyl group from a reagent to a target molecule is key for the reaction, and the reagents are classified according to their radical, nucleophilic ...
George Andrew Olah
George Andrew Olah (born in 1927, ) is a Hungarian and Americal chemist. He was awarded with the Nobel Prize in Chemistry 1994 for his work involving generation and reactivity of carbocations via ...
A Mild Ni/Cu-Catalyzed Silylation via C–O Cleavage
Zárate, C.; Martin, R. J. Am. Chem. Soc. 2014, ASAP. DOI: 10.1021/ja412107b A Ni/Cu-catalyzed silylation of unactivated C–O electrophiles derived from phenols or benzyl alcohols is described. This ...
Crabbe Allene Synthesis
Characteristics Crabbe allene synthesis (Crabbe homologation) is Cu-cataylzed synthesis of terminal allene compounds via homologation of acetylene precursors in the presence of diisopropylamine and ...
MIDA boronate
Characteristics N-methyliminodiacetic acid (MIDA) is very useful protecting group for boronic acid and forms stable (more stable that the free acid) boronates which are readily prepared from the ...
Amii Trifluoromethylation
Characteristics Amii trifluoromethylation is a the synthesis of trifluoromethylarenes from aryl/heteroaryliodides with CF3SiEt3 by Cu-catalsis. Selective introduction of trifluoromethyl ...
Merrifield Solid-Phase Peptide Synthesis
Characteristics A protein consists of one peptide folded in a particular way, or several peptides folded together. Such peptides are synthesised very rapidly within living cells, but until recently ...