Monthly Archives: October 2014

Seyferth-Gilbert Alkyne Synthesis

Seyferth-Gilbert Alkyne Synthesis

General Characteristics Aldehydes and ketones can be converted into alkynes with one carbon homologation using the α-diazophosphonate compound called the Gilbert reagent. When Y=H, the reaction needs ...

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Clemmensen Reduction

Clemmensen Reduction

General Characteristics The Clemmensen reduction is the reductive conversion of carbonyl groups into corresponding methylene units using zinc amalgam-HCl, which works particularly well for the ...

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Hofmann Rearrangement

Hofmann Rearrangement

General Characteristics In the Hofmann rearrangement, primary amides rearrange into isocyanates upon treatment with halogens and bases and are ultimately converted into primary amines with one-carbon ...

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