A heavy drug is a drug labeled with deuterium (2H, D).[1] By replacing C-H bonds at metabolic sites in drug molecules with more stable C-D bonds, metabolism can be slowed down. This deuteration makes ...
Posts by Category: Molecules
Super-Photostable Phosphole-Based Dye for Multiple-Acquisition Stimulated Emission Depletion Imaging
Chenguang Wang, Masayasu Taki, Yoshikatsu Sato, Aiko Fukazawa, Tetsuya Higashiyama, and Shigehiro Yamaguchi. J. Am. Chem. Soc., 2017, 139, 10374–10381. DOI: http://10.1021/jacs.7b04418 ...
Near-Infrared Dioxetane Luminophores with Direct Chemiluminescence Emission Mode
Ori Green, Samer Gnaim, Rachel Blau, Anat Eldar-Boock, Ronit Satchi-Fainaro, Doron Shabat. J. Am. Chem. Soc., 2017, 139, 13243–13248. DOI: 10.1021/jacs.7b08446 ABSTRACT Chemiluminescent luminophores ...
Family of BODIPY Photocages Cleaved by Single Photons of Visible/ Near-Infrared Light
Julie A. Peterson, Chamari Wijesooriya, Elizabeth J. Gehrmann, Kaitlyn M. Mahoney, Pratik P. Goswami, Toshia R. Albright, Aleem Syed, Andrew S. Dutton, Emily A. Smith, Arthur H. Winter. J. Am. Chem. ...
Caged Molecular Glues as Photoactivatable Tags for Nuclear Translocation of Guests in Living Cells
Akio Arisaka, Rina Mogaki, Kou Okuro, and Takuzo Aida. J. Am. Chem. Soc., 2018, 140, 2687–2692. DOI: 10.1021/jacs.7b13614 ABSTRACT We developed dendritic caged molecular glues (CagedGlue-R) as ...
Synthetic-Molecule/Protein Hybrid Probe with Fluorogenic Switch for Live-Cell Imaging of DNA Methylation
Yuichiro Hori, Norimichi Otomura, Ayuko Nishida, Miyako Nishiura, Maho Umeno, Isao Suetake, Kazuya Kikuchi. J. Am. Chem. Soc. 140, 5, 1686-1690. DOI: http://10.1021/jacs.7b09713 ABSTRACT ...
Visualizing Intercellular Tensile Forces by DNA-Based Membrane Molecular Probes
Bin Zhao, Casey O’Brien, Aruni P. K. K. Karunanayake Mudiyanselage, Ningwei Li, Yousef Bagheri, Rigumula Wu, Yubing Sun, Mingxu You. J. Am. Chem. Soc. 2017, 139, 18182−18185. ...
Development of a Light-Controlled Nanoplatform for Direct Nuclear Delivery of Molecular and Nanoscale Materials
Ya-Xuan Zhu, Hao-Ran Jia, Guang-Yu Pan, Nathan W. Ulrich, Zhan Chen, Fu-Gen Wu. J. Am. Chem. Soc. 2018, 140, 4062−4070. DOI: 10.1021/jacs.7b13672 Abstract Research on nanomedicines has rapidly ...
Development of a Series of Practical Fluorescent Chemical Tools To Measure pH Values in Living Samples
Shodai Takahashi, Yu Kagami, Kenjiro Hanaoka, Takuya Terai, Toru Komatsu, Tasuku Ueno, Masanobu Uchiyama, Ikuko Koyama-Honda, Noboru Mizushima, Tomohiko Taguchi, Hiroyuki Arai, Tetsuo Nagano, and ...
Molecular Machine –from Novel Prize in Chemistry 2016–
“Molecular machine” has been selected for the Nobel Prize in chemistry 2016. Although it is far from practical use, such basic research holds the possibility to change the future. We ...