General Characteristics Aromatic halides can be trifluoromethylated by copper-catalyzed cross coupling developed by Amii. This procedure is applicable to the introduction of other perfluoroalkyl ...
Tag Archives: trifluoromethyl group
Electrophilic Trifluoromethylation
General Characteristics Fluorine and hydrogen are about the same size, but are electronically very different. The substitution of hydrogen atoms with fluorine atoms is a common way of tuning the ...