General Characteristics When one wants to introduce perfluoroalkyl groups onto carbonyl groups by nucleophilic addition, she/he needs fluorine-containing organometallic reagents. However, these ...
Monthly Archives: March 2015
Takeda Olefination
General Characteristics The olefination of thioacetals via generation of organotitanium intermediates using divalent titanocene reagents is known as the Takeda olefination. The titanocene reagent ...
Aza-Wittig Reaction
General Characteristics Nucleophilic phosphorus reagents such as triphenylphosphine react with azides to generate, via the Staudinger reaction, N-P ylide (iminophosphorane) intermediates, which react ...
Takai-Lombardo Reaction
General Characteristics In the Takai olefination, carbonyl compounds are olefinated using organotitanium reagents derived from gem-dihaloalkanes. Whereas most of other olefination reactions are ...
Cross-coupling of functionalized olefins
Carbon-carbon bond formation is a basic reaction in organic chemistry, which builds the carbon skeleton in organic molecules. A vast number of carbon-carbon bond-forming reactions have been developed ...
Fine-tuned Supramolecular Polymerization
A class of polymeric materials called supramolecular polymers is drawing an attention in recently years. In contrast to “conventional” polymers, which consist of covalently linked monomeric units, ...
The Progress of Olefin Metathesis: Can It Handle Every Functional Group Now?
In January 2015, Yves Chauvin, the French chemist who was the first to propose the reaction mechanism of olefin metathesis, passed away. For his contribution, he shared the Nobel Prize in Chemistry ...