Monthly Archives: August 2014

Claisen Rearrangement

Claisen Rearrangement

General Characteristics The Claisen rearrangement is the [3,3]-sigmatropic rearrangement of allyl vinyl ethers producing γ,δ-unsaturated carbonyl compounds. This reactions is analogous to the Cope ...

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Yamaguchi Macrolactonization

Yamaguchi Macrolactonization

General Characteristics In the method developed by Yamaguchi, hydroxycarboxylic acids (“seco-acids”) are converted into reactive acid anhydrides using 2,4,6-trichlorobenzoyl chloride ...

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Organocuprates

Organocuprates

General Characteristics The organocuprate reagents [R2CuLi] prepared from copper(I) sources and two equivalents of organolithiums work as strong nucleophiles in 1,4-additions to α,β-unsaturated ...

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