Pomeranz-Fritsch Isoquinoline Synthesis

• General Characteristics

The condensation of benzaldehydes or arylketones with aminoacetaldehyde acetals gives isoquinolines.

Alternatively, the condensation of benzylamines with glyoxal hemiacetals also works for synthesizing the same products (the Schlittler-Muller modification).

• General References

Pomeranz, C. Monatsh 1893, 14, 116.

Fritsch, P. Ber. 1893, 26, 419.

Schlittler, E.; Muller, J. Helv. Chim. Acta 1948, 31, 914, 1119.

• Reaction Mechanism

• Examples

• Experimental Procedure

• Experimental Tips

• References

• Related Reactions

 Povarov Reaction

Camps Quinoline Synthesis

Conrad-Limpach Quinoline Synthesis

Combes Quinoline Synthesis

Niementowski Quinoline/Quinazoline Synthesis

Bischler-Napieralski Isoquinoline Synthesis

Pfitzinger Quinoline Synthesis

Skraup Quinoline Synthesis

Knorr Quinoline Synthesis

Friedländer Quinoline Synthesis

Pictet-Gams Isoquinoline Synthesis

Doebner-von Miller quinoline synthesis

Pictet-Spengler Reaction

Reissert Reaction

• Related Books

• External Links

Isoquinoline – Wikipedia

aminoacetaldehyde acetal, isoquinoline